Although this report does not forecast future outcomes, the data show the evolution of the United States in the global S&E enterprise. The United States continues to lead globally in R&D expenditures, S&E doctoral-level degree awards, and production of highly cited research publications. At the same time, other nations, particularly China, are rapidly developing their S&E capacity. As a result, the United States has seen its relative share of global S&T activity flatten or shrink, even as its absolute activity levels kept rising. As more countries around the world develop R&D and human capital infrastructure to sustain and compete in a knowledge-oriented economy, the United States is playing a less dominant role in many areas of S&E activity.